Evolution of functional mitral regurgitation and left atrial function in patients receiving cardiac resynchronization therapy

Abstract Background Left atrial (LA) function is a strong prognostic marker in patients with heart failure and functional mitral regurgitation (MR). Although cardiac resynchronization therapy (CRT) has shown to improve MR severity, the interaction between reduction severity an improvement LA function, as well their association outcomes, not been investigated. Purpose To investigate outcomes. Methods reservoir strain (RS) was evaluated speckle tracking echocardiography moderate severe MR. defined at least 1 grade 6 months after CRT implantation. The change LARS using multivariable logistic regression analysis. Patients were dividing into 3 groups: non-improvers; improvers no improvement; improvement. primary endpoint all-cause mortality. Results A total of 340 (mean age 66±10 years, 73% male) included, whom 200 (59%) showed On analysis, independently associated (OR 1.008; 95% CI 1.003–1.013; p=0.002) (Table 1). showing had lowest mortality rate, whereas outcomes significantly different non-improvers (p=0.236) (Figure Conclusion In HF significant MR, implantation LARS, which turn, better survival. Funding Acknowledgement Type funding sources: Other. Main source(s): ESC Training Grant App000064741